development of 153sm/177lu-edtmp as a possible therapeutic complex
Authors
abstract
introduction:targeted radionuclide therapy (trt) has been demonstrated to be an effective therapeutic tool in patients with disseminated bone metastasis. trt is generally performed with a single radionuclide. in this study we investigated the feasibility of combined trt with a high-energy beta emitter (153sm) and a low energy beta emitter (177lu) in wistar rats. methods: the cocktail complex of 153sm/177lu-edtmp was prepared. to determine the effect of metal-to-ligand (me:edtmp) molar ratio on labeling yield, several complex were analyzed after changing me:edtmp molar ratio from 1:1 to 1:50. 153sm/177lu-edtmp was administered intravenously through the tail vein of wistar rats. biodistribution data were collected at 2 hours to 7 day post injection and scintigraphic images were taken at 24 hours and 1, 2 week after administration of radiopharmaceutical. results: the results revealed high skeletal uptake (3.5% and 3.4% id/g at 24 hours post injection for 153sm and 177lu, respectively) with rapid blood clearance and minimal uptake in any of the major organs. scintigraphic images verified high skeletal uptake. conclusion: our results indicate that the combination of 153sm and 177lu is feasible and safe. this study suggests that the combination of different radionuclides with different radiation energies and half-life, such as 153sm and 177lu, could be advantageous in patients with tumoral lesions of different sizes.
similar resources
Development of 153Sm/177Lu-EDTMP as a possible therapeutic complex
Introduction:Targeted radionuclide therapy (TRT) has been demonstrated to be an effective therapeutic tool in patients with disseminated bone metastasis. TRT is generally performed with a single radionuclide. In this study we investigated the feasibility of combined TRT with a high-energy beta emitter (153Sm) and a low energy beta emitter (177Lu) in wistar...
full textPreparation of a 153Sm-5,10,15,20-tetrakis(4-methoxyphenyl) porphyrin complex as a possible therapeutic agent
Introduction: Porphyrins are interesting derivatives with low toxicity, tumor avidity and rapid wash-out suggested as potential radiopharmaceuticals in radiolabeled form. In this work we report, synthesis, radiolabeling, quality control, stability, partition coefficient determination and biodistribution studies of 153Sm-5,10,15,20-tetrakis(4-methoxyphenyl) porphyrin (153Sm-4-MPP) in ...
full textDevelopment and assessment of 153Sm-zoledronate complex as a possible bone pain palliative agent
Introduction:In this work, 153Sm-zoledronate (153Sm-ZLD) was studied using computational chemistry methods and prepared for possible use in bone pain palliation therapy. Methods: The Sm(ZLD)2.7H2O complex was synthesized and characterized in solid state using computational chemistry methods followed by 153...
full textpreparation of a 153sm-5,10,15,20-tetrakis(4-methoxyphenyl) porphyrin complex as a possible therapeutic agent
introduction: porphyrins are interesting derivatives with low toxicity, tumor avidity and rapid wash-out suggested as potential radiopharmaceuticals in radiolabeled form. in this work we report, synthesis, radiolabeling, quality control, stability, partition coefficient determination and biodistribution studies of 153sm-5,10,15,20-tetrakis(4-methoxyphenyl) porphyrin (153sm-4-mpp) in wild-type r...
full textBeyond Palliation: Therapeutic Applications of 153Samarium-EDTMP
Primary and metastatic malignant bone lesions result in significant pain and disability in oncology patients. Targeted bone-seeking radioisotopes including 153Samarium ethylene-diamine-tetramethylene-phosphonic acid (153Sm-EDTMP) have been shown to effectively palliate bone pain, often when external beam radiotherapy (EBRT) is not feasible. However, recent evidence also suggests 153Sm-EDTMP has...
full textMy Resources
Save resource for easier access later
Journal title:
iranian journal of nuclear medicineجلد ۲۵، شماره ۱، صفحات ۱۱-۱۶
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023